The Pathophysiology of Dry Eye Disease: An Underappreciated Story

Laura Periman, MD, Mark Milner, MD

Show Description +

Dry eye is more than just low tear production and an itchy, burning, gritty sensation. The pathophysiology of this condition is critical, and in the first edition of On the Surface, Laura Periman, MD, sits down with Mark Milner, MD, to address the topic. Drs. Periman and Milner review the latest literature and discuss the tear film, inflammation, what's happening on an immunological level, and more.

REFERENCES
Perry HD, Donnenfeld ED. Dry eye diagnosis and management in 2004. Curr Opin Ophthalmol. 2004;15(4):299-304.
Contreras-Ruiz L, Ghosh-Mitra A, Shatos MA, Dartt DA, Masli S. Modulation of conjunctival goblet cell function by inflammatory cytokines. Mediators Inflamm. 2013;2013:636812.

Posted: 1/31/2020

Keywords:

Dry Eye

•

Inflammation

•

Ocular surface

•

Tear Film

Up Next

Low-Level Light Therapies

Laura M. Periman, MD; and Darrell E. White, MD

Pulsed Light Patterns and Meibomian Gland Dysfunction

Laura M. Periman, MD; and Darrell E. White, MD

Hyperkeratinization in Meibomian Gland Dysfunction

Laura M. Periman, MD; and John A. Hovanesian, MD, FACS

Treating Neuropathic Corneal Pain With Low-Dose Naltrexone

Laura M. Periman, MD; and Pedram Hamrah, MD

Analyzing the Causes of Neuropathic Corneal Pain

Laura M. Periman, MD; and Pedram Hamrah, MD

The Link Between Dry Eye, Migraine Headache Disorder, and Ocular Pain

Laura M. Periman, MD; and Anat Galor, MD, MSPH

New Methods for Analyzing and Treating Neuropathic Ocular Pain

Laura M. Periman, MD; and Anat Galor, MD, MSPH

The Effects of Neurostimulation on Dry Eye Disease

Laura M. Periman, MD; and Vance Thompson, MD, FACS

The Influence of Dry Eye Disease on Overall Quality of Life

Laura M. Periman, MD, Scott Schachter, OD

Prevalence of Dry Eye Disease in Sleep Apnea Sufferers

Cynthia Matossian, MD, Laura M. Periman, MD

The Role of Screen Time in Dry Eye Disease

Josh Johnston, OD, FAAO, Laura M. Periman, MD

The Intersection of Dry Eye and Glaucoma

Inder Paul Singh, MD, Laura M. Periman, MD

Dry Eye Considerations in the Preoperative Surgical Patient

Christopher E. Starr, MD, FACS, Laura M. Periman, MD

A Deep Dive on the Connection Between Osmolarity and Keratometry in Cataract Surgery Patients

Alice T. Epitropoulos, MD, Laura Periman, MD

The Pathophysiology of Dry Eye Disease: An Underappreciated Story

Laura Periman, MD, Mark Milner, MD

Back to All Videos

The Pathophysiology of Dry Eye Disease: An Underappreciated Story

Laura Periman, MD, Mark Milner, MD

Posted: 1/31/2020

Keywords:

Dry Eye

•

Inflammation

•

Ocular surface

•

Tear Film

Please log in to leave a comment.

Comments

Robert Herrick

5 years ago

Punctal Occlusion is known to improve the health of the ocular surface, and the pre-corneal concentration of topically applied drops and medications (reducing systemic absorption by up to 60%). It elevates aqueous, lysozyme and other anti-bacterial and anti-microbial factors in the natural tear film, increases goblet cells and epithelial cells, decreases tear osmolarity and ocular inflammation. I consider punctal occlusion as adjunctive therapy when contemplating topical drug therapy in OSD and Ocular Allergy where Dry Eye is present. Punctal Occlusion in the upper puncta improves Dry Eyes signs and symptoms and allows undesirable inflammatory by-products to leave the eye's surface through the lower puncta. I recommend doing what Jeff Gilbard, PhD. used to suggest - "Don't let inflammation happen in the first place" (use hypotonic electrolyte balanced lubricating drops and Punctal Occlusion to reduce osmolarity and ocular inflammation)!