DURAVYU™ (vorolanib intravitreal insert)

Reinjection Criteria

Sophie Bakri, MD; Ehsan Rahimy, MD; and Lejla Vajzovic, MD

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Ehsan Rahimy, MD, and Lejla Vajzovic, MD, share safety data from the DAVIO 2 trial and the percentage of eyes that were supplement-free 6 months after treatment with EYP-1901. They explain how this treatment improved durability to help mitigate patients’ treatment and injection burdens and reduce visits to the office.

Posted: 5/16/2025

Keywords:

DURAVYU

•

vorolanib

•

EYP-1901

•

EyePoint Pharmaceuticals

•

TKI

•

tyrosine-kinase inhibitor

•

intravitreal insert

•

Age-Related Macular Degeneration (AMD)

•

Wet AMD

•

Diabetic macular edema, DME

•

An overview of TKIs and how they may fit into the wAMD treatment regimen

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Name: Reinjection Criteria
Uploaded: 2025-05-16T20:52:40+00:00
Description: Ehsan Rahimy, MD, and Lejla Vajzovic, MD, share safety data from the DAVIO 2 trial and the percentage of eyes that were supplement-free 6 months after treatment with EYP-1901. They explain how this treatment improved durability to help mitigate patients’ treatment and injection burdens and reduce visits to the office.

Patient Selection for EYP-1901

Sophie Bakri, MD; Ehsan Rahimy, MD; and Lejla Vajzovic, MD

An overview of TKIs and how they may fit into the wAMD treatment regimen

Why Do Real-World Wet AMD Outcomes Differ From Those Seen in Clinical Trials?

Sophie Bakri, MD; Durga S. Borkar, MD, MMCi; and Jayanth Sridhar, MD

Wet AMD and DME Therapy in Development

Sophie Bakri, MD; Durga S. Borkar, MD, MMCi; and Jayanth Sridhar, MD

TKIs: How Do They Work?

Sophie Bakri, MD; Durga S. Borkar, MD, MMCi; and Jayanth Sridhar, MD

What is EYP-1901 (DURAVYU™, (vorolanib intravitreal insert))?

Sophie Bakri, MD; Durga S. Borkar, MD, MMCi; and Jayanth Sridhar, MD

What Evidence Makes EYP-1901 a Potential Treatment for Wet AMD and DME?

Sophie Bakri, MD; Ehsan Rahimy, MD; and Lejla Vajzovic, MD

How Can a Multi-MOA Approach Benefit the Management of Wet AMD?

Sophie Bakri, MD; Ehsan Rahimy, MD; and Lejla Vajzovic, MD

Reinjection Criteria

Sophie Bakri, MD; Ehsan Rahimy, MD; and Lejla Vajzovic, MD

Patient Selection for EYP-1901

Sophie Bakri, MD; Ehsan Rahimy, MD; and Lejla Vajzovic, MD

Additional Videos

EYP1901 Mechanism of Action

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Reinjection Criteria

Sophie Bakri, MD; Ehsan Rahimy, MD; and Lejla Vajzovic, MD

Ehsan Rahimy, MD, and Lejla Vajzovic, MD, share safety data from the DAVIO 2 trial and the percentage of eyes that were supplement-free 6 months after treatment with EYP-1901. They explain how this treatment improved durability to help mitigate patients’ treatment and injection burdens and reduce visits to the office.

Posted: 5/16/2025

Keywords:

DURAVYU

•

vorolanib

•

EYP-1901

•

EyePoint Pharmaceuticals

•

TKI

•

tyrosine-kinase inhibitor

•

intravitreal insert

•

Age-Related Macular Degeneration (AMD)

•

Wet AMD

•

Diabetic macular edema, DME

•

An overview of TKIs and how they may fit into the wAMD treatment regimen

Resources

Addressing the Gaps in Duration of Treatment for Age-Related Macular Degeneration

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Scientific Publications

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About EyePoint, Inc

EYP-1901 is an investigational product and the safety and efficacy of EYP-1901 has not been established. FDA has not approved EYP-1901 in the United States. The materials discussed on this site do not predict future FDA approval. Conclusive evidence of efficacy and safety of EYP-1901 will require further investigation in well-controlled Phase 3 clinical trials

Visit us online: eyepointpharma.com

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DURAVYU™ has been conditionally accepted by the FDA as the proprietary name for EYP-1901. DURAVYU™ is an investigational product; it has not been approved by the FDA. FDA approval and the timeline for potential approval is uncertain.

DURAVYU (EYP-1901), is an investigational sustained delivery treatment for VEGF-mediated retinal diseases combining vorolanib, a selective and patent-protected tyrosine kinase inhibitor with Durasert E™ - efficacy and safety have not yet been established with well controlled, phase 3 pivotal trials.