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Important Risk Information about LOTEMAX® GEL
- LOTEMAX® Gel is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures.
- Intraocular pressure (IOP) increase - Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision. If this product is used for 10 days or longer, IOP should be monitored.
- Cataracts - Use of corticosteroids may result in posterior subcapsular cataract formation.
- Delayed healing - Use of steroids after cataract surgery may delay healing and increase the incidence of bleb formation and occurrence of perforations in those with diseases causing corneal and scleral thinning. The initial prescription and renewal of the medication order should be made by a physician only after examination of the patient with the aid of magnification.
- Bacterial infections - Prolonged use of corticosteroids may suppress the host response and thus increase the hazard of secondary ocular infection. In acute purulent conditions, steroids may mask infection or enhance existing infections.
- Viral infections - Use of corticosteroid medication in the treatment of patients with a history of herpes simplex requires great caution. Use of ocular steroids may prolong the course and exacerbate the severity of many viral infections of the eye (including herpes simplex).
- Fungal infections - Fungal infections of the cornea are particularly prone to develop coincidentally with long-term local steroid application. Fungus invasion must be considered in any persistent corneal ulceration where a steroid has been used or in use.
- Contact lens wear - Patients should not wear contact lenses when using LOTEMAX® Gel.
- The most common ocular adverse drug reactions were anterior chamber inflammation (5%), eye pain (2%) and foreign body sensation (2%). Please see full prescribing information for LOTEMAX® Gel.
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LOTEMAX® Gel: the newest formulation of loteprednol etabonate
by Karl Stonecipher MD, Sheri Rowen, MD
LOTEMAX® Gel (loteprednol etabonate ophthalmic gel) 0.5% is available for the treatment of post-operative inflammation and pain following ocular surgery.
In this video Karl Stonecipher, MD, of TLC Laser Centers, and Sheri Rowen, MD, of Rowen Laser Vision & Cosmetic Center, discuss the benefits of the the gel formulation over the Lotemax suspension formulation, and how its design overcomes some of the obstacles of ocular drug delivery.